3F-PCP (3-Fluorophencyclidine) | Analytical Reference Standard

Are you seeking a verified, high-purity source for buy 3-Fluoro-PCP online in Europe? 3F-PCP (3-fluorophencyclidine) is a potent dissociative agent of the arylcyclohexylamine class. As a structural analog of PCP, it features a fluorine substitution at the meta-position of the phenyl ring. Within the scientific community, it is a primary subject for researchers investigating the Structure-Activity Relationship (SAR) of halogenated dissociatives and the impact of the “fluorine effect” on receptor affinity and metabolic stability.

We provide analytical-grade 3F-PCP hydrochloride, verified via HPLC and GC-MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and structural biology studies.

Pharmacological Profile & Mechanism of Action

3F-PCP is utilized as a sophisticated chemical probe to study the biochemical markers of central nervous system (CNS) modulation. Researchers utilize this compound to explore:

NMDA Receptor Antagonism: Acting as a high-affinity non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor. It binds to the PCP site within the ion channel, modulating excitatory neurotransmission.
Monoamine Reuptake Inhibition: Investigating its potency as an inhibitor for the dopamine transporter (DAT) and norepinephrine transporter (NET). The 3-fluoro substitution is often studied for its ability to balance dissociative and stimulatory properties.
The Fluorine Effect: Studying how the high electronegativity and small atomic radius of fluorine influence the molecule’s lipophilicity, metabolic resistance to hydroxylation, and binding kinetics compared to PCP or 3-MeO-PCP.

Primary Research & Forensic Applications

Buy 3-Fluoro-PCP online in Europe is an essential reference material for several advanced scientific domains:

Neuroscience Research: Exploring the modulation of neuronal signaling and the impact of 3-position fluorination on the potency and selectivity of arylcyclohexylamines.
Forensic Toxicology: Serving as a validated reference standard (CAS: 72242-03-6 or related isomers) for LC-MS/MS and GC-MS libraries to identify and quantify novel psychoactive substances (NPS).
Structure-Activity Relationship (SAR) Mapping: Utilizing 3F-PCP as a probe to understand how isosteric replacements (replacing hydrogen or methoxy with fluorine) alter the compound’s pharmacological footprint.
Metabolic Mapping: Investigating the metabolic pathways of fluorinated dissociatives, focusing on the stability of the aryl-fluorine bond during hepatic processing.

Technical Specifications

Feature	Details
IUPAC Name	1-[1-(3-fluorophenyl)cyclohexyl]piperidine
CAS Number	123010-09-5
Molar Mass	261.38 g/mol (Base)
Purity Grade	Analytical Research Grade ( $\geq$ 98%)
Molecular Formula	$C_{17}H_{24}FN \cdot HCl$

Safety, Regulatory Status, and Procurement

3F-PCP is intended strictly for laboratory research and is NOT for human or veterinary consumption.

Regulatory Compliance: Researchers must ensure procurement aligns with local jurisdictional laws regarding PCP analogs. 3F-PCP is frequently subject to “analogue” legislation or designer drug bans.
Handling & PPE: Due to extreme physiological activity at low milligram levels, the use of Personal Protective Equipment (PPE), including nitrile gloves, eye protection, and a fume hood, is mandatory.
Storage: To maintain maximum molecular stability, store in a cool, dry, and dark environment in airtight containers.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure your research is conducted with materials of known concentration and high purity.
Chain of Custody: Professional logistics ensure tracked, secure shipping, maintaining the compliance required for institutional and academic facilities.
Technical Documentation: Orders are supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

Buy 3-Fluoro-PCP online in Europe

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