4-Cl-α-PVP (4-Chloro-α-pyrrolidinopentiophenone) | Analytical Reference Standard

Are you seeking a verified, high-purity source for buy 4-Cl-α-PVP online in Europe? 4-Chloro-α-pyrrolidinopentiophenone (also known as 4-Cl-PVP or 4-Chloro-PVP) is a synthetic stimulant of the pyrrolidinophenone class. As a structural analog of α-PVP (Flakka), it features a chlorine substitution at the para-position of the phenyl ring. Within the scientific community, it is a primary subject for researchers investigating the Structure-Activity Relationship (SAR) of halogenated stimulants and the development of high-resolution forensic detection assays.

We provide analytical-grade 4-Cl-α-PVP hydrochloride, verified via HPLC and GC-MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and toxicological studies.

Pharmacological Profile & Mechanism of Action

The addition of the chlorine atom at the 4-position significantly alters the electronic density of the phenyl ring, affecting its metabolic stability and receptor affinity. Researchers utilize 4-Cl-α-PVP to study:

Potent DAT/NET Inhibition: Investigating the compound’s action as a selective reuptake inhibitor of the dopamine transporter (DAT) and norepinephrine transporter (NET).
Halogenation Dynamics: Studying how the chlorine atom influences the molecule’s lipophilicity and its ability to cross the blood-brain barrier compared to α-PVP or 4F-α-PVP.
Pyrrolidine Ring Activity: Exploring the impact of the pyrrolidine moiety on the binding kinetics and residence time at the monoamine transporter sites.

Primary Research & Forensic Applications

Buy 4-Cl-α-PVP online in Europe is an essential reference material for several advanced scientific domains:

Forensic Toxicology: Serving as a validated reference standard (CAS: 1354634-10-8 or related isomers) for LC-MS/MS and GC-MS libraries to identify and quantify novel psychoactive substances (NPS) in complex biological matrices.
Neuroscience Research: Exploring the impact of chlorinated pyrrolidinophenones on extracellular neurotransmitter concentrations and potential neurotoxicological profiles.
Metabolic Mapping: Investigating the primary metabolic pathways of chlorinated cathinone analogs, specifically the oxidation of the pyrrolidine ring and aryl hydroxylation.
Isomeric Differentiation: Utilizing 4-Cl-α-PVP as a comparative standard to distinguish para-substituted isomers from ortho or meta counterparts during analytical testing.

Technical Specifications

Feature	Details
IUPAC Name	1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one
Chemical Class	Substituted Pyrrolidinophenone
Molar Mass	265.78 g/mol (Base)
Purity Grade	Analytical Research Grade ( $\geq$ 98%)
Molecular Formula	$C_{15}H_{20}ClNO \cdot HCl$

Safety, Regulatory Status, and Procurement

4-Cl-α-PVP is intended strictly for laboratory research and is NOT for human or veterinary consumption.

Regulatory Compliance: Researchers must ensure procurement aligns with local jurisdictional laws. 4-Cl-α-PVP is frequently subject to “analogue” legislation or specific Novel Psychoactive Substance (NPS) bans.
Handling & PPE: Due to high physiological activity and potency, the use of Personal Protective Equipment (PPE), including nitrile gloves, eye protection, and a fume hood, is mandatory.
Storage: To maintain chemical integrity, store in a cool, dry, and dark environment in airtight containers.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure your research is conducted with materials of known concentration and high purity.
Professional Logistics: Secure, tracked shipping ensures that institutional research programs remain uninterrupted and compliant with regulatory requirements.
Technical Documentation: Orders are supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

Buy 4-Cl-α-PVP online in Europe

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