Buy Clonazolam Reference Standards Online | Certified Forensic Calibration Material

Elite Chem Science provides certified, high-purity Clonazolam analytical reference materials to support state forensic laboratories, academic biochemical research groups, and automated clinical toxicology networks globally. Because Clonazolam is characterized by its exceptionally high potency at microgram levels, clinical and forensic analysts require authenticated, certified reference benchmarks to secure accurate quantitative linearity, validate extraction efficiencies, and eliminate false-positive assignments in complex multi-analyte assays.

Our reference standards are synthesized and tightly monitored within controlled facilities to guarantee complete batch-to-batch structural integrity. Every lot is distributed with exhaustive analytical validation data, confirming chemical identity via high-field nuclear magnetic resonance (NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS) profiling.

Advanced Chemical Profile & Mass Spectrometry Dynamics

Clonazolam (systematically designated as 6-(2-chlorophenyl)-1-methyl-8-nitro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine) is a synthetic triazolobenzodiazepine derivative. Structurally, it combines structural features from both clonazepam and alprazolam, integrating a highly electronegative nitro group ($-\text{NO}_2$) at the 8-position of the core benzene ring and a chlorine atom substitution at the ortho-position of the 6-phenyl ring, all fused to a methyl-substituted triazole framework.

This complex arrangement of dense halogenated and nitro substituents fundamentally alters the molecule’s chemical characteristics. The nitro and chlorine groups significantly increase its electronegativity and reverse-phase liquid chromatography (RP-HPLC) retention time compared to non-substituted triazolobenzodiazepines. When analyzed via electrospray ionization tandem mass spectrometry (ESI-MS/MS), the fragmentation pathway produces highly specific, clean ion splits across the central diazepine ring system. Utilizing an authenticated matrix is essential to isolate Clonazolam cleanly from metabolic breakdown products or closely related isomers like flualprazolam.

Technical Specifications Matrix

Mandatory Laboratory Safety & Compliance Proclamation

Clonazolam is prepared exclusively as an analytical reference standard for laboratory research, forensic validation assays, and certified in vitro diagnostic processes. Due to strict scheduling updates and international drug monitoring frameworks, distribution is restricted strictly to licensed institutional accounts. This material is fundamentally not intended for human, clinical, therapeutic, or veterinary administration. All manipulation must proceed inside an authorized facility using verified containment hoods and standard personal protective equipment (PPE).

Frequently Asked Questions (FAQ)

What specific mass spectrometry transitions dictate Clonazolam identification?

In positive-mode electrospray ionization (ESI+), Clonazolam presents a distinct protonated molecular parent ion $[M+H]^+$ at m/z 354.1. Under collision-induced dissociation (CID), it generates highly reproducible, diagnostic product fragments at m/z 308.1 (corresponding to the loss of the nitro group component) and m/z 281.0, which serve as core monitoring vectors for definitive multi-reaction monitoring (MRM) quantification.

How are Clonazolam reference standards stabilized against structural drift?

To preserve the integrity of the nitro structure and the fused triazole network against ambient hydrolysis, crystalline Clonazolam reference standards must be stored hermetically sealed in their original amber vials inside a laboratory freezer held steadily at or below -20°C.

What verification documentation ships with an elite procurement lot?

Every batch distributed is supported by an immutable, lot-specific Certificate of Analysis (CoA). This official packet details the absolute purity verification profile, raw high-performance liquid chromatography (HPLC) traces, interpreted Proton NMR spectra, and a fully compliant Safety Data Sheet (SDS).

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Maintain absolute data validation integrity across your laboratory’s toxicological testing pipelines.

Contact our compliance and procurement department today to verify your institutional research credentials and request an official bulk quotation.