3-HO-PCE (3-Hydroxyeticyclidine) | Analytical Reference Standard

Are you seeking a verified, high-purity source for buy 3-HO-PCE online in Europe? 3-HO-PCE (3-hydroxyeticyclidine) is a potent dissociative anesthetic belonging to the arylcyclohexylamine class. It is the 3-hydroxy derivative of PCE (Eticyclidine). Within the scientific community, it is a primary subject for researchers investigating the Structure-Activity Relationship (SAR) of glutamate receptors and the metabolic pathways of N-ethylated arylcyclohexylamines.

We provide analytical-grade 3-HO-PCE hydrochloride, verified via HPLC and LC-MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and structural biology studies.

Pharmacological Profile & Mechanism of Action

buy 3-HO-PCE online in Europe, is utilized as a chemical probe to study the biochemical markers of central nervous system (CNS) modulation. Researchers utilize this compound to explore:

NMDA Receptor Antagonism: Primarily acting as a high-affinity non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor. Investigations focus on its binding efficacy within the PCP site of the ion channel.
Opioid Receptor Affinity: Studying the compound’s unique affinity for the $\mu$ -opioid receptor, a characteristic shared with its structural analog 3-HO-PCP, which distinguishes it from many other dissociatives.
Monoamine Reuptake Inhibition: Researching its secondary effects as a reuptake inhibitor for dopamine and norepinephrine, contributing to its complex neurochemical profile.

Primary Research & Forensic Applications

3-HO-PCE is an essential reference material for several advanced scientific domains:

Neuroscience Research: Exploring the modulation of neuronal signaling and the impact of 3-substituted arylcyclohexylamines on synaptic plasticity.
Forensic Toxicology: Serving as a validated reference standard (CAS: 79787-43-2) for LC-MS/MS and GC-MS libraries to identify and quantify novel psychoactive substances (NPS) in complex biological matrices.
Metabolic Mapping: Investigating the primary metabolic pathways of N-ethylated analogs, specifically the hydroxylation of the cyclohexyl ring and N-dealkylation.
Comparative Pharmacology: Utilizing 3-HO-PCE to differentiate the potency and duration of action across the PCE and PCP derivative families.

Technical Specifications

Feature	Details
IUPAC Name	3-[1-(ethylamino)cyclohexyl]phenol
CAS Number	79787-43-2
Molar Mass	219.33 g/mol (Base)
Purity Grade	Analytical Research Grade ( $\geq$ 98%)
Molecular Formula	$C_{14}H_{21}NO \cdot HCl$

Safety, Regulatory Status, and Procurement

3-HO-PCE is intended strictly for laboratory research and is NOT for human or veterinary consumption.

Regulatory Compliance: Researchers must ensure procurement aligns with local jurisdictional laws regarding arylcyclohexylamines. In many regions, 3-HO-PCE is categorized under analogues legislation or novel psychoactive substance acts.
Handling & PPE: Due to high physiological activity at low milligram levels, the use of Personal Protective Equipment (PPE), including nitrile gloves, eye protection, and a fume hood, is mandatory.
Storage: To maintain maximum chemical integrity, store in a cool, dry, and dark environment in airtight containers.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure your research is conducted with materials of known concentration and high purity.
Professional Logistics: Secure, tracked shipping ensures that institutional research programs remain uninterrupted and compliant with chain-of-custody requirements.
Technical Documentation: Orders are supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

Buy 3-HO-PCE online in Europe

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