4-AcO-MET (4-Acetoxy-N-methyl-N-ethyltryptamine) | Analytical Reference Standard

Are you seeking a verified, high-purity source for buy 4-AcO-MET online in Europe? 4-AcO-MET (4-acetoxy-N-methyl-N-ethyltryptamine), also known as Metacetin, is a synthetic tryptamine derivative. It is the acetylated analog of 4-HO-MET (Metocin) and a structural relative of psilacetin (4-AcO-DMT). Within the scientific community, it is a primary subject for researchers investigating the Structure-Activity Relationship (SAR) of asymmetric N,N-dialkyltryptamines and the metabolic kinetics of indole esters.

We provide analytical-grade 4-AcO-MET fumarate, verified via HPLC and GC-MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and structural biology studies.

Pharmacological Profile & Mechanism of Action

4-AcO-MET is primarily studied as a prodrug, where the acetoxy group is hypothesized to undergo rapid in vivo hydrolysis by esterases to yield the active pharmacophore, 4-HO-MET. Researchers utilize this compound to explore:

Serotonergic Agonism: Investigating the binding affinity and intrinsic activity at the $5\text{-HT}_{2\text{A}}$ receptor, as well as $5\text{-HT}_{1\text{A}}$ and $5\text{-HT}_{2\text{C}}$ subtypes.
Asymmetric Alkylation: Studying how the asymmetric N-methyl-N-ethyl substitution influences metabolic stability and receptor residence time compared to symmetric analogs like 4-AcO-DMT or 4-AcO-DET.
Indole Ring Substitution: Characterized by an acetoxy group at the 4-position. Researchers study how this modification alters the molecule’s lipophilicity and its ability to cross the blood-brain barrier.

Primary Research & Forensic Applications

Buy 4-AcO-MET online in Europe is an essential reference material for several advanced scientific domains:

Neuroscience Research: Exploring the modulation of neuronal signaling and the impact of 4-substituted tryptamines on synaptic plasticity and serotonin system mapping.
Forensic Toxicology: Serving as a validated reference standard (CAS: 1445751-40-5) for LC-MS/MS and GC-MS libraries to identify and quantify novel psychoactive substances (NPS) in complex biological matrices.
Metabolic Mapping: Investigating the esterase-mediated hydrolysis pathways in in-vitro human hepatic and plasma models.
Comparative Pharmacology: Utilizing 4-AcO-MET to differentiate the potency across the 4-substituted tryptamine family, providing baseline data for SAR modeling.

Technical Specifications

Feature	Details
IUPAC Name	[3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate
CAS Number	1445751-40-5
Molar Mass	260.33 g/mol (Base)
Purity Grade	Analytical Research Grade ( $\geq$ 98%)
Molecular Formula	$C_{15}H_{20}N_{2}O_{2} \cdot C_{4}H_{4}O_{4}$ (Fumarate)

Safety, Regulatory Status, and Procurement

4-AcO-MET is intended strictly for laboratory research and is NOT for human or veterinary consumption.

Regulatory Compliance: Researchers must ensure procurement aligns with local jurisdictional laws. 4-AcO-MET may fall under “analogue” acts or specific novel substance regulations in the US, UK, and EU.
Handling & PPE: Due to high physiological activity, the use of Personal Protective Equipment (PPE), including nitrile gloves, eye protection, and a fume hood, is mandatory.
Storage: To maintain chemical stability and prevent premature hydrolysis, store in a cool, dry, and dark environment (preferably at -20°C for long-term storage) in airtight containers.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure your research is conducted with materials of known concentration and high purity.
Chain of Custody: Professional logistics ensure tracked, secure shipping, maintaining the compliance required for institutional and academic facilities.
Technical Documentation: Orders are supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

Buy 4-AcO-MET online in Europe

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