3-HO-PCP (3-Hydroxyphencyclidine) | Analytical Reference Standard

Are you seeking a verified, high-purity source for buy 3-HO-PCP online in Europe? 3-HO-PCP (3-hydroxyphencyclidine) is a potent dissociative of the arylcyclohexylamine class and a prominent hydroxylated derivative of PCP (Phencyclidine). Within the scientific community, it is a primary subject for researchers investigating NMDA receptor antagonism and the unique structural modifications that introduce opioid receptor affinity into the arylcyclohexylamine backbone.

We provide analytical-grade 3-HO-PCP hydrochloride, verified via HPLC and LC-MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and structural biology studies.

Pharmacological Profile & Mechanism of Action

3-HO-PCP is utilized as a sophisticated chemical probe to study the biochemical markers of central nervous system (CNS) modulation. Researchers utilize this compound to explore:

NMDA Receptor Antagonism: Acting as a high-affinity non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor. It binds to the PCP site within the ion channel, blocking the influx of cations.
Mu-Opioid Receptor ( $\mu$ -OR) Affinity: Unlike many other dissociatives, 3-HO-PCP exhibits significant affinity for the $\mu$ -opioid receptor. This dual-action profile makes it an essential tool for studying the interplay between glutamate and opioid signaling pathways.
Dopaminergic Modulation: Researching its activity as a D2 receptor partial agonist and its role in inhibiting the reuptake of monoamine neurotransmitters.

Primary Research & Forensic Applications

buy 3-HO-PCP online in Europe is an essential reference material for several advanced scientific domains:

Neuroscience Research: Exploring the modulation of neuronal signaling and the impact of 3-position hydroxylation on the potency of arylcyclohexylamines.
Forensic Toxicology: Serving as a validated reference standard (CAS: 79787-43-2 or 106128-91-2) for LC-MS/MS and GC-MS libraries to identify and quantify novel psychoactive substances (NPS).
Structure-Activity Relationship (SAR) Mapping: Utilizing 3-HO-PCP as a probe to understand how small structural changes alter the selectivity between NMDA and opioid targets.
Metabolic Mapping: Investigating the metabolic stability of hydroxylated PCP analogs in in-vitro human hepatic models.

Technical Specifications

Feature	Details
IUPAC Name	3-[1-(piperidin-1-yl)cyclohexyl]phenol
CAS Number	79787-43-2
Molar Mass	259.39 g/mol (Base)
Purity Grade	Analytical Research Grade ( $\geq$ 98%)
Molecular Formula	$C_{17}H_{25}NO \cdot HCl$

Safety, Regulatory Status, and Procurement

3-HO-PCP is intended strictly for laboratory research and is NOT for human or veterinary consumption.

Regulatory Compliance: Researchers must ensure procurement aligns with local jurisdictional laws regarding PCP analogs. In many regions, 3-HO-PCP is controlled under “analogue” or “designer drug” legislation.
Handling & PPE: Due to extreme physiological activity at low milligram levels, the use of Personal Protective Equipment (PPE), including nitrile gloves, eye protection, and a fume hood, is mandatory.
Storage: To maintain maximum molecular stability, store in a cool, dry, and dark environment in airtight containers.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure your research is conducted with materials of known concentration and high purity.
Chain of Custody: Professional logistics ensure tracked, secure shipping, maintaining the compliance required for institutional and academic facilities.
Technical Documentation: Orders are supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

Buy 3-HO-PCP online in Europe

Advance your neuropharmacological and forensic investigations with certified buy 3-HO-PCP online in Europe. Contact our specialized distribution team today to secure high-purity materials for your facility.