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€ 200,00 – € 2.100,00Price range: € 200,00 through € 2.100,00
Buy S-23 Powder Online at Elite Chem Sciences
Certified Selective Androgen Receptor Modulator (SARM) Reference Materials for High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Quantification, and Receptor Binding Assays
When academic research teams, forensic science laboratories, and private biochemical institutes seek to buy S-23 Powder online at elite chem sciences, securing absolute batch-to-batch homogeneity and verified structural purity is critical to eliminating background experimental variables. Known chemically as (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, S-23 is a highly functionalized, non-steroidal selective androgen receptor modulator (SARM) belonging to the aryl propionamide class. Developed as a structural evolution of early-generation tissue-selective ligands, S-23 features a di-halogenated phenoxy core that provides exceptionally high binding affinity ($K_i$) for the androgen receptor ($AR$).
Because the freebase propionamide skeleton can exhibit vulnerability to atmospheric degradation and mechanical handling errors if left exposed, Elite Chem Sciences delivers this specialized reference standard exclusively as a dense, finely crystallized powder matrix. This approach provides predictable dissolution metrics, sharp peak symmetry, and fully reproducible structural fragmentation profiles during advanced laboratory screenings.
By establishing an unbroken supply chain with Elite Chem Sciences, your facility ensures clear chromatographic separation, clean mass spectrometry fragmentation profiles, and complete data validation across all testing arrays.
Advanced Applications in Endocrine Research
1. Aryl Propionamide Homology and Structure-Activity Relationships (SAR)
S-23 serves as a foundational structural probe for exploring how dual halogen substitutions on the phenoxy ring affect receptor pocket alignment. Its design features a chlorine atom at the 4-position and a fluorine atom at the 3-position, bound directly to a trifluoromethyl-substituted benzonitrile ring. This specific structural layout significantly shifts the molecule’s overall dipole moment, electron density distribution, and spatial orientation within the androgen receptor ligand-binding domain (LBD). Research teams deploy this powder standard to map competitive binding kinetics, structural stability, and coregulator recruitment dynamics in cell-free assays.
2. High-Resolution Anti-Doping Calibration & Forensic Screening
Establishing precise chromatographic baseline separation is a fundamental requirement for validation registries, sports anti-doping facilities, and forensic drug screening laboratories. Because functionalized SARMs, their synthesis precursors, and related positional isomers can present closely overlapping elution windows under standard setups, utilizing our certified powder standards allows identification laboratories to register exact retention indices, fine-tune mobile phase pH parameters, and maintain precise ultraviolet-visible (UV-Vis) and mass spectrometry baseline separation.
3. In Vitro Metabolic Mapping and Phase I/II Conjugation Kinetics
The halogenated phenoxy architecture and central amide linkage within the S-23 framework represent critical focal points for checking chemical durability and enzyme-driven cleavage profiles. Research teams utilize this high-purity powder to map oxidative monohydroxylation, ether cleavage, and glucuronidation kinetics across liver microsome and cell-free matrix simulations over time, documenting how structural modifications alter compound availability compared to loose unfluorinated variants.
Master Specification Data Matrix
| Analytical Compound Matrix | Molecular Formula | Molecular Weight | Physical Matrix Format | Standard Unit Packaging | Baseline Assay Purity | Validated Testing Modalities |
| S-23 Powder Standard | $C_{18}H_{13}\text{ClF}_4N_2O_3$ | $416.75 \text{ g/mol}$ | Crystalline Powder | Amber Borosilicate Vial | $\ge$ 98.5% (HPLC) | HPLC / $^1\text{H}$-NMR / LC-MS |
Reconstitution & Stock Preparation Protocol
To solubilize the crystalline powder efficiently and minimize quantitative mass errors during solution preparation, laboratory technicians should follow this validation sequence:
Allow the amber vial to reach ambient room temperature inside a dry glove box environment prior to opening to prevent atmospheric water condensation. Weigh out the necessary micro-milligram fraction using a calibrated analytical balance.
Quantitatively transfer the powder into an unreactive amber borosilicate vial and introduce high-purity laboratory solvent to hit the target stock concentration (e.g., $10.0 \text{ mg/mL}$). S-23 displays optimized dissolution kinetics when processed using HPLC-grade absolute ethanol, anhydrous acetonitrile, or dimethyl sulfoxide (DMSO).
Secure the vial cap tightly and lower it into an ice-cooled sonication bath. Agitate the fluid mixture for 6 to 8 minutes, keeping the bath temperature strictly under 15°C to preserve the structural integrity of the central amide and ether links against unexpected thermal stress.
Pass the dissolved fluid mixture through a 0.22 $\mu\text{m}$ hydrophobic PTFE syringe filter straight into a clean autosampler vial for system injection. This step removes fine particulates and protects system loops from contamination.
Search Intent FAQ Block (Rich Snippet Optimization)
Q: How does S-23 fragment under liquid chromatography-tandem mass spectrometry (LC-MS/MS) during trace target verification?
A: Under negative mode electrospray ionization ($-1 \text{ ESI-MS}$), S-23 generates a highly visible deprotonated precursor molecular ion $[M-H]^-$ at $m/z$ 415.0. Upon collision-induced dissociation (CID), this non-steroidal ligand undergoes highly reproducible fragmentation across its central ether and amide bonds. The primary diagnostic paths yield prominent product fragment ions at $m/z$ 205.0 (corresponding to the 4-amino-2-(trifluoromethyl)benzonitrile component) and $m/z$ 145.0 (the chloro-fluorophenoxy fragment). This specific structural mass footprint allows forensic and anti-doping laboratories to definitively confirm the identity of the target analyte.
Q: What solvent configurations ensure maximum shelf-life for reconstituted S-23 stock reference standards?
A: Because the propionamide skeleton can undergo gradual amide-bond hydrolysis if stored in environments with trace aqueous moisture or alkaline impurities, stock solutions must be prepared using degassed, completely anhydrous HPLC-grade acetonitrile or DMSO to maintain maximum peak stability inside glass vials. Reconstituted standards should be split into single-use aliquots, stored under an inert nitrogen blanket, and kept frozen below $-20^\circ\text{C}$ to prevent degradation.
Why Leading Global Laboratories Choose Elite Chem Sciences
Procuring critical analytical compounds demands an industry-aligned partner capable of guaranteeing strict quality control, structural validation, and reliable transport infrastructure. Elite Chem Sciences delivers on every tier:
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Uncompromising, Batch-Verified Purity: Every batch of S-23 powder undergoes rigorous high-performance liquid chromatography (HPLC) testing and nuclear magnetic resonance (NMR) analysis. We certify a baseline purity threshold of 98.5% or higher, eliminating background chemical noise from your data arrays.
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Optimized Crystal Formats: Our dynamic crystal precipitation pipelines ensure a highly uniform powder matrix, reducing mechanical agglomeration and facilitating ultra-precise micro-pipetting or weight measurement.
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Secure, Advanced Data Privacy Protocols: Our institutional procurement infrastructure operates on robust, end-to-end cryptographic layers, protecting purchase histories, payment structures, and sensitive corporate or academic research parameters from unauthorized exposure.
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Discreet, Environmentally Shielded Shipping: Shipments are safely isolated in light-blocking, moisture-impermeable, multi-layered neutral packaging. Every order includes complete tracking to maintain a reliable chain of custody straight to your receiving deck.
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Exhaustive Technical and Compliance Logs: Each order includes digital and hard-copy analytical packets containing up-to-date Safety Data Sheets (SDS), detailed storage directives, and lot-specific Certificates of Analysis (CoA) to ensure complete alignment with high-purity analytical reagents compliance frameworks.
Safety and Regulatory Information
IMPORTANT: All analytical compounds and reference substrates distributed by Elite Chem Sciences are supplied strictly and exclusively for professional laboratory, academic testing, and forensic verification frameworks.
STRICTLY NOT intended for human or animal consumption, inhalation, or in vivo administration of any kind.
NOT intended for medical therapies, clinical diagnostics, prescription use, or veterinary treatments.
Must be handled exclusively within certified laboratory facilities by trained personnel utilizing proper personal protective equipment (PPE), including chemical-resistant gloves and eye protection.
Global scheduling laws and import restrictions are highly dynamic. The ordering institution or individual bears full, sole responsibility for confirming local legality and obtaining any necessary import permits before completing checkout.
Equip Your Research Infrastructure
Ensure absolute analytical precision, sharp peak separation, and flawless data reproducibility in your next screening series.
[Buy S-23 Powder Online at Elite Chem Sciences]
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| Quantity | 15g, 245g(80oz+), 30g(1oz+), 480g(160z+) |
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